Formulation Development and Optimization

1. Design and optimization of oral tablets for poorly water-soluble drugs using solid dispersion techniques.
2. Development of sustained-release matrix tablets for drugs with a short half-life.
3. Investigation of natural gum-based polymers for controlled drug release.
4. Formulation and evaluation of mucoadhesive buccal tablets for local drug delivery.
5. Study on the impact of particle size reduction on solubility and bioavailability of hydrophobic drugs.
6. Development of bioenhanced oral formulations using novel excipients.
7. Formulation and optimization of effervescent tablets for high-dose drugs.
8. Development of self-microemulsifying drug delivery systems (SMEDDS) for lipid-soluble drugs.
9. Investigation of multi-unit pellet system (MUPS) technology for sustained-release formulations.
10. Optimization of co-processed excipients for improved tablet compaction properties.
11. Formulation and characterization of floating drug delivery systems for gastric retention.
12. Study on the effect of binder concentration on drug release from wet granulated tablets.
13. Formulation of nanosuspensions for enhancing dissolution rate of poorly soluble APIs.
14. Evaluation of the role of surfactants in improving drug solubility in oral formulations.
15. Development of dispersible tablet formulations for pediatric patients in India.

Manufacturing Process Optimization

16. Development and optimization of wet granulation processes for tablet production.
17. Implementation of inline quality control techniques during tablet compression.
18. Study on the effects of compression force on hardness and dissolution of tablets.
19. Evaluation of high-shear granulation for uniformity in large-scale production.
20. Optimization of parameters for film coating of solid oral dosage forms.
21. Study on the scalability of fluid bed drying for granules with varying particle sizes.
22. Application of twin-screw extrusion for manufacturing sustained-release tablets.
23. Implementation of continuous manufacturing techniques for oral solid dosage forms in Indian industries.
24. Optimization of roller compaction parameters for manufacturing moisture-sensitive drugs.
25. Evaluation of rotary tablet press performance for high-speed production in Indian pharmaceutical plants.
26. Development of scalable processes for manufacturing soft gelatin capsules.
27. Process validation and optimization of lyophilization cycles for biological products.
28. Investigation of the impact of mixing parameters on homogeneity of drug blends.
29. Optimization of spray drying parameters for heat-sensitive APIs.
30. Study on minimizing material wastage during tablet compression in large-scale production.

Quality Control and Regulatory Compliance

31. Development and validation of analytical methods for API quantification in bulk and formulations.
32. Stability studies of oral dosage forms under accelerated storage conditions as per Indian regulatory guidelines.
33. Study on the impact of packaging materials on drug stability during transportation.
34. Comparative evaluation of quality control parameters of branded and generic tablets in India.
35. Validation of cleaning processes for manufacturing equipment in Indian pharmaceutical plants.
36. Evaluation of dissolution profiles of sustained-release tablets for regulatory compliance.
37. Analytical method development for simultaneous estimation of drugs in combination products.
38. Risk assessment and mitigation strategies in manufacturing sterile products.
39. Investigation of the role of good manufacturing practices (GMP) in reducing cross-contamination.
40. Development of protocols for handling deviations during pharmaceutical manufacturing.
41. Study on the implementation of quality by design (QbD) in tablet formulations.
42. Regulatory assessment of labeling and packaging requirements for exported pharmaceutical products.
43. Validation of analytical methods for residual solvents in tablet formulations.
44. Assessment of batch-to-batch uniformity in solid oral dosage forms.
45. Evaluation of extractable and leachable substances from pharmaceutical packaging materials.

Advanced Technologies in Drug Delivery

46. Formulation and evaluation of 3D-printed oral tablets for customized dosing.
47. Development of polymer-based nanoparticles for targeted drug delivery.
48. Formulation of fast-dissolving oral films using solvent casting techniques.
49. Development and optimization of transdermal patches for anti-inflammatory drugs.
50. Investigation of liposomes as carriers for poorly soluble drugs.
51. Study on the use of microneedles for intradermal delivery of vaccines.
52. Formulation of thermoresponsive in-situ gels for ophthalmic drug delivery.
53. Development of injectable depot formulations for long-acting drug delivery.
54. Optimization of nanosponges for delivery of anti-cancer agents.
55. Evaluation of supercritical fluid technology for preparation of drug-loaded nanoparticles.
56. Study on the use of cyclodextrins for solubilizing poorly water-soluble drugs.
57. Development of implantable drug delivery systems for chronic diseases.
58. Formulation of oral mucoadhesive gels for controlled drug release.
59. Investigation of biodegradable polymers for use in injectable drug delivery systems.
60. Study on the application of iontophoresis for transdermal drug delivery.

Sustainability in Pharmaceutical Manufacturing

61. Investigation of green solvents for API synthesis in pharmaceutical manufacturing.
62. Development of energy-efficient drying techniques for pharmaceutical granules.
63. Assessment of water reuse and recycling strategies in pharmaceutical manufacturing units.
64. Investigation of biodegradable polymers for primary and secondary packaging of drugs.
65. Development of eco-friendly tablet film coatings using natural polymers.
66. Study on waste minimization strategies during tablet compression and coating processes.
67. Application of life cycle assessment (LCA) in evaluating environmental impact of pharmaceutical products.
68. Investigation of alternative energy sources for manufacturing plants in India.
69. Study on reducing emissions from effluent treatment plants in pharmaceutical industries.
70. Optimization of process flow to reduce carbon footprint in pharmaceutical manufacturing.
71. Development of sustainable methods for solvent recovery in API manufacturing.
72. Use of enzymatic processes for green synthesis of pharmaceutical intermediates.
73. Assessment of biodegradable packaging materials for parenteral drugs.
74. Investigation of cost-effective methods for reducing solid waste during manufacturing.
75. Study on implementation of green chemistry principles in large-scale production of APIs.

Emerging Areas in Industrial Pharmacy

76. Development of machine learning models for predicting drug formulation stability.
77. Use of artificial intelligence in optimizing pharmaceutical process parameters.
78. Investigation of blockchain technology for improving traceability in pharmaceutical supply chains.
79. Implementation of automation in packaging and labeling for error reduction.
80. Study on predictive maintenance of pharmaceutical manufacturing equipment using IoT.
81. Investigation of digital twin technology for simulation of pharmaceutical processes.
82. Development of smart pharmaceutical packaging for temperature-sensitive drugs.
83. Application of robotic systems in cleanroom manufacturing of sterile products.
84. Use of real-time monitoring systems for process optimization in Indian pharmaceutical industries.
85. Study on the role of augmented reality (AR) in pharmaceutical training and troubleshooting.
86. Implementation of big data analytics in quality control for pharmaceutical manufacturing.
87. Investigation of cloud-based solutions for regulatory document management.
88. Development of voice-controlled systems for pharmaceutical production.
89. Evaluation of cybersecurity challenges in pharmaceutical automation systems.
90. Study on digital tools for ensuring regulatory compliance during manufacturing.

Process Validation and Scale-Up

91. Process validation and scale-up of oral liquid formulations in a pharmaceutical industry.
92. Validation of tablet coating parameters for large-scale production.
93. Scale-up challenges for hot-melt extrusion techniques in manufacturing.
94. Investigation of critical process parameters during fluid bed granulation.
95. Validation of aseptic techniques in sterile product manufacturing.
96. Study on scale-up of nanosuspension formulations for commercialization.
97. Process validation of inline mixing techniques for bulk drug manufacturing.
98. Scale-up of multi-layered tablet manufacturing processes for combination therapy.
99. Validation of drying techniques for reducing residual moisture in granules.
100. Investigation of scale-up parameters for injectable emulsion formulations.
101. Study on validation of blending efficiency for high-shear mixers in Indian industries.